Design, Synthesis and Antibacterial Activities of Triazole-Pyrimidine Derivatives as SecA Inhibitors

Background: To highlight the magnitude of important challenge now facing scientists, drug resistance needs exploration novel antimicrobial agents. The identification new and vital target in bacteria then designing their inhibitors can be explored. Thus, targeting SecA, a central component bacterial general secretion system, is promising strategy for development antimicrobials. Objective: evaluate compounds as SecA synthesized by structural modification bistriazole SCA-21. Method: A were evaluated antibacterial activity against Escherichia coli NR698 (E. leaky mutant), Staphylococcus aureus (S. aureus) Bacillus anthracis (B. anthracis). Results: Some triazole-pyrimidine derivatives known inhibitor SCA 21 structures confirmed 1H NMR, 13C NMR Mass spectral analysis. compound showed E. (a S. aureus B. anthracis Sterne. Conclusion: Five designed, inhibitors. At end this study, 259 with azide pentyl group was found most potent inhibitor. It expressed better inhibitory ATPase than else 21.